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During most seasons, people 65 years and older bear the greatest burden of severe flu disease, accounting for the majority of flu-related hospitalizations and deaths.

For the 2022-2023 flu season, the CDC recommends any one of three flu vaccines for people 65 years and older: Fluzone High-Dose Quadrivalent vaccine, Flublok Quadrivalent recombinant flu vaccine and Fluad Quadrivalent adjuvanted flu vaccine.

This recommendation was based on a review of available studies, which suggested that these vaccines are potentially more effective than standard dose unadjuvanted flu vaccines for people 65 years and older.